When people suffer from depression, the general performance is depressed, very sad, not in the mood to do things, feel sorry for others, self guilty; less talk, do not want to answer people, less activity, decreased interest; since they feel incapable, anything to do can not be done; there are sleep disorders, sexual function decline, appetite decline. Some patients have suicidal thoughts and behaviors. However, some patients have the above-mentioned performance is relatively light; but manifested as: chest tightness, breathlessness, back discomfort; some even appear “angina pectoris”. Checking myocardial enzymes, electrocardiogram but no great abnormalities. In fact, it is the patient’s somatization when the depression; that is, the performance like having “angina” is actually depression. Some tests show “slight myocardial ischemia”, and the patient may be convinced that the patient has a “heart attack” rather than a mental illness. There are also problems with doctors’ judgment. Some people feel “like they are going to die, their heart feels like it is going to jump out, and they are very frightened”, which is a kind of “panic disorder” associated with depression. In one case, the patient had a heart “bypass” surgery, and often felt “precordial discomfort” and anxiety after the surgery; later, he took antidepressants to get better. Therefore, these patients do not visit the cardiovascular department, the psychology department should be seen to determine what the problem is, before the next step in treatment.