The patient wakes up between 3:00 and 5:00 in the morning, which is often caused by liver qi stagnation or excessive liver fire. This type of patient can be treated with Xiao Chai Hu Tang, or Zhuan Yao Wan, depending on the patient’s pathological mechanism to adjust the prescription, that is, depending on the patient’s systemic symptoms, appropriate adjustment, some patients need to use Si Wei San, or Da Chai Hu Tang. In addition, whether the patient can fall asleep quickly after waking up between 3:00 and 5:00, or cannot fall asleep after waking up, is also a difference in treatment. If it is very difficult to fall asleep again, some sedative and sleeping drugs can be added appropriately.