Antiseptic, also known as spironolactone, is a clinically used potassium-preserving diuretic. It is mainly used clinically for the treatment of edematous diseases, such as congestive edema, ascites caused by various types of cirrhosis, nephrogenic edema, idiopathic edema, etc. It is also used clinically as an adjunct to the treatment of hypertension, and for the treatment of primary aldosteronism and the prevention of hypokalemia. Oral administration of spironolactone can increase the diuretic effect and prevent hypokalemia. For the treatment of edematous diseases, the daily dose for adults is 40-120 mg in 2-4 oral doses for at least 5 days. For the treatment of hypertensive disorders the initial dose is 40-80 mg orally in divided doses for at least 2 weeks. Clinical adverse reactions such as hyperkalemia, hyponatremia, and allergic reactions are common. Antiseptic mainly acts on the distal convoluted tubules and collecting ducts, the clinical diuretic effect is relatively weak and needs to be combined with other diuretic drugs to increase the clinical effect.