In case of fever during choledochal endoscopic stone extraction and drainage, physical cooling and antipyretic medication may be given in the early stage; it may also be caused by postoperative infection, which requires anti-infective treatment. Choledochal endoscopic lithotripsy usually damages the bile duct, causing an inflammatory response, which in turn can lead to postoperative fever due to stimulation by inflammatory factors and other mediators. When the fever temperature is low, physical cooling can be performed, such as axillary rubbing of warm water or alcohol, which in turn reduces the body temperature. For higher fever temperatures, such as greater than 38.5°C, fever-reducing medications such as cotrimoxazole can be injected to lower the fever and avoid causing adverse reactions; oral fever-reducing medications such as acetaminophen can also be taken. In addition, after choledochal endoscopy stone extraction can also be due to postoperative infection fever symptoms, can be adjusted according to the blood routine, calcitoninogen, bile culture and other results of antibiotic medication, drugs include cefuroxime, cefoperazone and so on. Fever in choledochotomy endoscopic stone drainage should be timely consultation, according to the condition and specific medication.