Pancreatic cancer is called “the king of cancers”, due to its high degree of malignancy, difficult to diagnose, once found, it is often in advanced stage, therefore, the cure rate is very low. According to statistics, even in Europe and the United States, once diagnosed with pancreatic cancer, its five-year survival rate is less than 10%. Many celebrities, such as former national leader Huang Ju, former Minister of Health Chen Minzhang, Apple founder Steve Jobs, and famous singer Pavarotti, have passed away because of this disease. In addition to the low survival rate, pancreatic cancer has a very obvious symptom, that is, it is often accompanied by severe pain, usually in the upper abdomen, at first relatively mild (in the absence of a diagnosis, it is often treated as a gastric disease and easy to misdiagnose), but later more and more serious, many patients are also accompanied by low back pain, and they can only bend down to get a little better, and there are also patients in pain who can’t sleep the whole night, and they can only Some patients could not sleep all night because of the pain and could only sleep sitting up. To the patients, the pain can really be described as “worse than death”. Generally speaking, medication is the first choice for cancer pain treatment, and the three-step medication recommended by WHO can control the pain of 80% of cancer pain patients. Opioids (e.g. Tramadol, Mescaline, Oxycontin, Fentanyl transdermal patches, morphine tablets, etc.) are the main medications used for cancer pain treatment. However, the common adverse effects of opioids, such as nausea and vomiting, constipation, and the patient’s concern about addiction, limit the degree of pain control by pure medication to a certain extent, and there are about 10-20% of the patients who are unable to be controlled by medication or have serious adverse effects that make it difficult for patients to accept the medication. Serious adverse reactions make it difficult for patients to accept, and this is especially true for pain caused by abdominal tumors such as pancreatic cancer. The reasons are as follows: 1, abdominal pain caused by pancreatic cancer often belongs to the pain of incomplete response to opioids, in order to control this pain, sometimes a larger dose of opioids is needed; 2, pancreatic cancer patients themselves will be more serious nausea, vomiting and gastrointestinal dysfunction, and the application of large doses of opioids add to the patient’s symptoms, so even if the patient’s pain can be controlled, nausea, vomiting and constipation and other serious symptoms are not controlled, the patient’s pain is not controlled. Therefore, even if the patient’s pain can be controlled, serious adverse effects such as nausea, vomiting and constipation will greatly reduce the patient’s quality of life. So, is there a way or means to relieve the pain caused by pancreatic cancer and at the same time allow no or less medication to be taken, thus reducing or avoiding the adverse effects caused by medication and enabling patients to be more comfortable? Our answer is: yes! Since the sensory transmission of the pancreas, bile ducts, stomach and duodenum and other upper abdominal organs are mainly innervated by the abdominal plexus, we can make the pain signals sent by pancreatic cancer not to be transmitted to the brain through the abdominal plexus destruction technology (similar to pinching off the wires, so that the electric current does not conduct to the light bulb, so that the light bulb will not be lit). In this way, the patient’s pain will be well controlled, and the patient’s use of opioids will be greatly reduced, or even stop using pain medication, nausea and vomiting, constipation and other symptoms are also greatly reduced as a result. At the same time, due to the abdominal plexus is sympathetic plexus, after being blocked, intestinal peristalsis will be accelerated, to a certain extent, also reduces constipation and other adverse reactions. So, which patients are suitable for abdominal plexus disruption? What is the pain relief effect of abdominal plexus disruption? How to do it? What are the adverse reactions? Is it traumatic? Let us answer one by one: 1. Since the nerves from the stomach to the upper end of the transverse colon are basically innervated by the abdominal plexus, not only pancreatic cancer, but also cholangiocarcinoma, gastric cancer, hepatocellular carcinoma, as well as other parts of the tumor metastasized to the peritoneum resulting in epigastric pain can be relieved by abdominal plexus disruption. 2. Previous researches have shown that the effectiveness of abdominal plexus for cancer pain caused by upper abdominal tumors is relatively high, especially for abdominal pain and low back pain caused by pancreatic cancer, and its effectiveness rate can reach more than 80%, and in experienced hospitals, if the indications are chosen appropriately and the puncture is precise, the effectiveness rate can even reach more than 90%. 3, the abdominal plexus is generally in a fixed position, basically located in front of the abdominal aorta and below the abdominal trunk. Therefore, it is possible to use an ultra-fine puncture needle with a diameter of 0.5mm under CT guidance to precisely puncture the tip of the needle around the peritoneal plexus and inject the destructive drug. Therefore, the trauma is very small. How small is it? After it is done, you may not even be able to see the eye of the needle. Because of its small trauma, so even the poorer patients can tolerate. 4, the abdominal plexus is sympathetic plexus, and the spinal nerves that innervate the activities of our limbs, the two are different in nature (similar to different electrical wires and circuit systems), therefore, abdominal plexus destruction generally does not lead to lower limb paralysis and other complications. However, the sympathetic nerves are inhibited and the vagus nerves are relatively hyperactive after the destruction, and there may be transient hypotension (usually within a few hours, and rehydration fluids can be used) and diarrhea (usually lasts for about 1 week, and symptomatic treatment can be used. Previously constipated patients may constipation will improve as a result). 5, in view of the abdominal plexus destruction of epigastric pain control is highly effective, less traumatic, and relatively mild adverse effects, therefore, many guidelines recommend that patients with indications should be carried out as soon as possible (for example, small doses of opioids can not control poorly or can not tolerate the adverse effects can be carried out), instead of having to wait until the effect of high-dose drug therapy is not good before, early to do early benefit. 6. Due to nerve regeneration and tumor progression, the effect of abdominal plexus destruction usually lasts for 3-6 months, but after the pain worsens again, the destruction can be repeated to make the pain under control again.