Perineal pain may be caused by physiological factors, eczema, prostatitis, trauma, vaginitis and so on. Different causes, the treatment of drugs will be different, patients should be under the guidance of the doctor to use drugs, avoid self-medication. 1. Physiological factors: patients sitting for a long time will lead to perineal pain, which is a normal physiological phenomenon, after appropriate rest, can be relieved. 2. Vulvar eczema: usually due to pathogen infection, mental factors, endocrine disorders lead to perineum pimples, blisters and other symptoms, accompanied by itching, pain and so on. Patients can follow the doctor’s instructions to use erythromycin ointment, hydrocortisone ointment, tacrolimus ointment and other drugs for treatment. 3. Prostatitis: Due to the distribution of many blood vessels near the prostate, when it is stimulated by inflammation, pain in the perineum may occur, and can be treated with tamsulosin and finasteride tablets. 4. Trauma: pain may occur when the perineum is hit by external force. 5. Vaginitis: when the mucous membrane of the perineum is stimulated by inflammation and other stimuli, it may cause pain in the perineum. Patients with perineal pain should go to the hospital and take medication under the guidance of the doctor, avoiding blind self-medication to avoid adverse consequences.