Late-night numbness and swelling of the calf and knee should be treated according to the cause of general treatment, drug treatment, physical therapy and surgical treatment, etc. Common causes include lower limb compression, osteoarthritis, lumbar intervertebral disc herniation, and vascular diseases of the lower limbs. 1. Lower limb compression: the lower limb blood vessels and nerves are compressed due to incorrect posture during late-night sleep, causing numbness and swelling in the calf and knee, which can be relieved by changing the posture and resting. 2. Osteoarthritis: usually should pay attention to rest, strengthen the knee joint warmth. Non-steroidal anti-inflammatory drugs can be used, such as celecoxib and so on. Physical therapy such as massage and hot compresses are also available. If the symptoms are serious and conservative treatment is ineffective, knee replacement surgery is feasible. 3. Lumbar disc herniation: The more serious cases of lumbar disc herniation will lead to nerve compression in the lumbar spine, and the lower limbs innervated by the nerves may experience pain and numbness. The patient should rest in bed, and can take oral methylcobalamin and other nutritive nerve drugs, as well as ibuprofen and other non-steroidal anti-inflammatory drugs for treatment, and can also be baked electricity, massage and other physical therapy. Severe symptoms, conservative treatment is ineffective, feasible minimally invasive nucleus pulposus removal surgery and other surgical treatments. 4. Lower extremity vascular disease: such as vascular occlusive vasculitis, atherosclerosis and other diseases, can improve blood circulation in the lower extremities through physical therapy such as hot compresses, but also oral aspirin and other antiplatelet drugs. Late at night calf knee numbness may also be caused by other reasons, such as traumatic arthritis, etc., if the rest does not relieve, it is recommended to consult a doctor in a timely manner, improve the examination to clarify the cause of the disease, and comply with the doctor’s instructions for targeted treatment. The above drugs are recommended to be used under the guidance of a physician.