Long closed mouth that is acne, may be related to high androgen levels, follicle sebaceous gland duct keratinization abnormality, sebaceous gland secretion increase, etc., to the cause of drug or physical therapy. 1. For those caused by high androgen level, oral anti-androgen drugs such as spironolactone can be taken as prescribed by the doctor; physical therapy such as photodynamic therapy can inhibit sebum secretion. 2. For those caused by abnormal keratinization of follicular sebaceous ducts, topical retinoids such as retinoic acid ointment and oral retinoids can be used as prescribed by the doctor; physical therapy such as photodynamic therapy can improve the keratinization of follicular sebaceous ducts. 3. for sebaceous gland secretion increased, should pay attention to skin cleaning, usually pay attention to avoid staying up all night, light diet can reduce sebaceous gland secretion to a certain extent, if necessary, oral vitamin B6 and other medication. It is recommended that long closed mouth and have to remove the demand for timely medical attention, clear cause, under the guidance of the doctor for standardized treatment, do not self-medication.