There is no so-called simplest way to determine endometrial cancer, which includes comprehensive analysis of medical history, clinical examination, auxiliary examination and pathological examination. Medical history mainly refers to the symptoms of vaginal bleeding, vaginal discharge and lower abdominal pain in post-menopausal women, while pre-menopausal women mostly show disturbed menstrual cycle, prolonged menstrual period or increased menstrual flow, and sometimes can also show irregular vaginal bleeding. Clinical examination includes gynecological triple diagnostic examination, paying attention to uterine size, mobility and the presence of parietal tissue infiltration. Adjunctive examination mainly refers to cytologic examination, hysteroscopy, vaginal ultrasound, uterine and adnexal ultrasound, etc. In addition, lower abdominal pelvic CT and magnetic resonance imaging can also assist in the diagnosis. Pathologic examination mainly involves endometrial biopsy or diagnostic scraping through hysteroscopy, of which the most commonly used and effective means of examination is segmental diagnostic scraping. Endometrial cancer can be diagnosed clinically through the above examinations.