Premature ovarian failure clinically refers to early-onset ovarian insufficiency, a disease that cannot be cured and can only be treated to alleviate symptoms. Early onset ovarian insufficiency is a hypogonadal disease that occurs in women before the age of 40. The specific cause of this disease is not clear, and it is considered to be related to chromosomal abnormality, autoimmune diseases, infections and other factors, so it is not possible to eliminate the cause of the disease from the root, and even if it is treated, it will not be able to restore the normal function of the ovaries completely. Early detection of ovarian insufficiency is based on drug treatment, supplementation of estrogen and progesterone, such as nil estradiol, dydrogesterone, progesterone capsules, or direct use of estrogen and progesterone composite preparations, such as estradiol/estradiol dydrogesterone tablets. Symptoms such as amenorrhea, hot flashes, insomnia, vaginal dryness and low libido can usually be well improved after standardized treatment. If you are diagnosed with ovarian insufficiency, you should follow the doctor’s instructions for treatment, not self-medication, go to the hospital for review on time, and communicate with your doctor in time to understand the degree of recovery.