Whether bilirubin 150 mmol/L is serious or not cannot be generalized, but depends on factors such as overall liver function results, primary disease, the presence of comorbidities, and the presence of timely and standardized treatment. If the overall liver function results are abnormal, or if there are obvious primary illnesses or complications, and there is no timely medical treatment and standardized treatment, this situation will be more serious. 1. Overall liver function results: Liver function includes many indicators, bilirubin is only one of the many indicators, and needs to be analyzed together with other tests, such as alanine aminotransferase and glutamic oxalate aminotransferase. 2. Primary disease: Bilirubin 150mmol/L may be caused by hemolytic jaundice or cirrhosis, and the prognosis of the two treatments is completely different. In the former case, the prognosis is generally better with active treatment; advanced cirrhosis generally progresses progressively. 3. Comorbidity: if it is multi-organ and multi-tissue damage, it will be more serious than single organ problem. 4. Timely and standardized treatment: the prognosis of patients who can be treated in a timely and standardized way will be better than those who are not treated in a timely and standardized way. To summarize, if bilirubin 150mmol/L is present, it is recommended that the patient should consult a doctor in time to find out the cause and have comprehensive treatment.