The main side effect of glimepiride is hypoglycemia, followed by nausea, vomiting, diarrhea, liver function impairment. Glimepiride is an insulinotropic agent, the mechanism of action is to promote the pancreatic β-cell secretion of insulin to lower blood glucose, usually taken on an empty stomach, the common side effect is hypoglycemia, especially common in the elderly and frail, irregular eating, drinking, as well as liver and kidney insufficiency of patients. In addition, digestive symptoms including nausea, vomiting, diarrhea, and abdominal pain may occur. It may also cause elevated serum aminotransferases leading to hepatic insufficiency, skin allergic reactions such as itching, erythema, and urticaria. Headache, weakness, dizziness, hair loss, and weight gain may also be seen with glimepiride use. If any of these adverse reactions occur while taking Glimepiride, you should go to the hospital and adjust your treatment program under the guidance of your doctor.