A painful fleshy bump on the vulva may be due to local inflammation, mostly seen in folliculitis, but also inflammation of the soft tissue of the vulva. Most of them are accompanied by local redness, swelling, heat and pain. You need to see a doctor in time to check and confirm the diagnosis and then give the appropriate treatment. If it is considered to be due to inflammation, you can use sterile cotton swabs dipped in iodophor solution to apply disinfection, or use Bactrim, or you can use erythromycin ointment. If the pain is obvious, at the same time, you need to use antibiotics orally or by injection under the guidance of a doctor, for example, you can take amoxicillin capsules or azithromycin dispersible tablets orally. If the inflammation is severe, penicillin or cephalosporin antibiotics can be ordered, and azithromycin can also be infused.