Gallbladder polyps refer to a group of diseases that broadly refer to lesions that protrude or bulge into the lumen of the gallbladder and are mostly benign. They can be divided into neoplastic polyps, such as adenomas and adenocarcinomas, and non-neoplastic polyps, such as cholesterol polyps and inflammatory polyps adenomatous hyperplasia. They are collectively referred to as gallbladder polypoid lesions because of the difficulty in determining their nature before surgery. Most of them are asymptomatic. However, the following conditions are considered as risk factors for malignant lesions: diameter over 1 cm, age over 50 years, solitary lesion, progressive increase in polyp size, restricted thickening of the gallbladder wall or wide basal polyps, combined gallbladder stones, etc. Surgery should be considered for those with significant symptoms and those with the above risk factors for malignancy. In your case, I personally consider that surgery should be considered. Myelofibrosis and anemia are only relative contraindications to surgery, and anemia should be corrected as much as possible before surgery.