Long-term intake of large amounts of coffee can lead to bone loss, and in severe cases can lead to osteoporosis, because coffee contains caffeine, which can affect calcium absorption and affect bone calcium deposition. It can also cause the proliferation of osteoclasts, promote osteoclastic effect, leading to the inhibition of osteoblast activity, osteogenesis is weakened, a large loss of calcium ions in the bones, coffee has diuretic function, can accelerate the metabolism of calcium. In general, it leads to a large loss of calcium in the body, causing osteoporosis, caffeine can cause excitement, affect the quality of sleep, affect the immune system, will lead to a decline in the body’s immunity, is not conducive to physical recovery, is not conducive to the deposition of calcium, it is not recommended to drink a lot of coffee for a long time. Coffee also avoid drinking at night to prevent sleep deprivation, affecting the growth of bone, try to avoid drinking large amounts of coffee for a long time.