Tiredness after taking two months of prednisone acetate may be related to physiological factors, underlying diseases and other diseases, or it may be caused by drugs, such as drug side effects. 1. Physiological factors: if the patient sleeps in a noisy environment at night or drinks more tea or coffee during the day, resulting in poor sleep quality at night, daytime fatigue may occur. 2. Underlying diseases: If the patient suffers from nephrotic syndrome, chronic nephritis and other diseases, and takes prednisone acetate during the treatment, if there is fatigue, it can be considered as the cause of hypoproteinemia. 3. Other diseases: If the patient has low potassium or low blood sugar, the symptoms of fatigue may also appear. 4. Drug side effects: If the patient does not take prednisone acetate as prescribed by the doctor, but take a large dose, there will be weakness, abdominal pain, diarrhea, nausea, vomiting and other adverse reactions. If the patient ate two months after the prednisone acetate weakness, it is recommended that the patient in a timely manner regular hospital medical care, under the guidance of specialists to identify the causes and active treatment.