Glibenclamide is used for the treatment of diabetes mellitus, and adverse reactions include diarrhea, rash, and jaundice. 1. Action: It is used for the treatment of non-insulin-dependent diabetes mellitus with poor dietary control, in which the patient’s β-cells have some insulin-secreting function and there are no serious complications. 2. Side effects: diarrhea, rash, jaundice and so on. (1) Common side effects are diarrhea, nausea, vomiting, stomach pain, headache and so on. (2) Rarely, there is rash. (3) Rare but more serious ones are jaundice, bone marrow suppression, liver function impairment, thrombocytopenia, etc. 3. It is contraindicated in patients with type 1 diabetes mellitus and patients with type 2 diabetes mellitus accompanied by coma, burns, infections, and trauma. If you need to take glibenclamide, it is recommended to standardize the use of medication under the guidance of a doctor.