Lumps on the calf hurt when pressed may be caused by muscle injury, lower extremity venous thrombosis or calf osteophytes. 1. Muscle injury: If running, hiking and other high-intensity sports cause bleeding after muscle injury, resulting in subcutaneous hematoma, a hard knot will be formed in the leg, and pain when pressed. 2. Venous thrombosis: If the patient suffers from venous thrombosis, thrombus may be formed in the vein at the early stage of the disease, resulting in lumps and hard knots, and pain when pressed. 3. Osteomalacia: Osteomalacia is a kind of pathological process of self-repair of the body, generally it is the slow degeneration and aging of the human body’s bones and joints, and the thin and weak people may have hard lumps and nodules which can be touched. Most of the osteophytes will not produce uncomfortable symptoms, but if it involves the peripheral nerves, it will cause pain, swelling, numbness and other uncomfortable symptoms. Because of the lump on the calf on the pressure on the pain of more causes also include bone tumors and knee joint free body, etc., if through conservative treatment can not be effectively improved, it is recommended to go to the hospital in a timely manner to check the diagnosis, as soon as possible to determine the cause of the disease to take targeted therapeutic measures, to avoid delaying the condition led to the aggravation of the symptoms.