The susceptibility to urticaria during menstruation is caused by changes in the body’s immune function during menstruation. Urticaria is related to the body’s constitution, immune status, and stimulation by external allergens. If hives always appear during menstruation, it is likely to be due to changes in the immune function of the body during menstruation. Therefore, during menstruation, it is necessary to make adjustments on your own and keep a good mental state. During menstruation, the level of sex hormones in women’s bodies changes more significantly, including the decline in the levels of progesterone and estrogen, which will affect the immune state. Moreover, during menstruation, women’s mental state fluctuates greatly, such as nervousness, anxiety, irritability, etc., will also affect the immune function through the neuroimmune pathway, which will easily lead to the emergence of urticaria symptoms. The appearance of urticaria is recommended to timely hospital consultation, follow the doctor’s instructions for treatment.