Decreased albumin-globulin ratio is seen in, for example, chronic moderate or persistent hepatitis, cirrhosis, primary liver cancer, and other severe liver impairment diseases.
White protein is synthesized in the liver and decreases when liver damage reaches a certain level; globulin is produced by the body’s immune organs and increases when viral antigens are present in the body.
The body’s indicators reflecting the synthetic function of the liver include total protein, albumin, and cholesterol. The total serum protein is the sum of serum albumin and globulin, and a decrease in total protein is often seen in conjunction with a decrease in albumin.
Serum total protein and albumin tests are used to reflect chronic liver damage, such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma, when hepatocyte protein synthesis is impaired, resulting in decreased protein synthesis and thus decreased total serum protein, mainly albumin.
Patients with chronic liver disease have an inverted A/G ratio due to impaired hepatic synthesis, resulting in decreased albumin levels, and increased globulin production due to the presence of hepatitis viruses in the body.