White spots on the tongue are generally caused by oral candida infection, treatment can be local drug therapy and systemic antifungal therapy, usually without excision, as follows. 1. Local medication: (1) 2%~4% sodium bicarbonate solution: gargling can inhibit the growth and reproduction of Candida. (2) Cediriodine tablets: strong anti-inflammatory and bactericidal ability and suitable for mixed infections. 2. Systemic antifungal treatment: (1) Fluconazole: it can inhibit the synthesis of ergosterol, which is the main component of fungal cell membrane, and it has a long-lasting antifungal effect in the tissues. (2) Itraconazole: oral preparation can be used to treat superficial fungal infections. All of the above drugs need to be used under the guidance of a doctor, there may be other reasons for white spots on the tip of the tongue, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease after targeted treatment.