Epilepsy is a common disease in psychiatry, and although there is no obvious gender difference in the onset of epilepsy, there are still some issues that need special attention when dealing with epilepsy for women with epilepsy due to special physiological factors. 1, the impact of epilepsy drugs on appearance: love of beauty is common, but some anti-epileptic drugs have a great impact on the outside. Some drugs taken for a long time can make women’s skin rough, lips thicken, facial and scalp subcutaneous tissue thicken, nose widen, facial hairy, etc. Long-term use of phenytoinamide can cause gum enlargement, and patients should pay special attention to oral hygiene and take folic acid supplements to prevent gum enlargement. Some can cause weight gain, such as sodium valproate, especially when the dose is high, and special attention should be paid to obese women who are already overweight taking valproate. 2. Puberty and epilepsy: About 25% of female patients have their first seizures during menarche, and about 60% of patients who have been diagnosed with epilepsy before menarche have increased seizure frequency and symptoms during menarche. Therefore, it is recommended to increase the dose in adolescent patients who do not have stable seizure control; even if complete control is proposed to be discontinued for 3 years or more, it should be considered to be postponed. 3. Menstruation and epilepsy: Studies have found that estrogen in women can increase sensitivity to seizures and cause seizures during menstruation, while progesterone can increase the activity of the inhibitory piece of the menstrual inverse, causing a decrease in the excitatory piece of nerve cells, thus playing a role in seizure inhibition. Changes in the levels of both directly affect the severity of seizures in women with epilepsy. Starting from the premenstrual period, the progesterone level decreases and the ratio of estrogen to progesterone gradually increases, and this phase is the peak seizure period. Ten days after menstruation, progesterone underwater peaks and the ratio of estrogen to progesterone decreases, making this phase the low peak of seizures. The metabolism of antiepileptic drugs also varies with the menstrual cycle. During the menstrual period, patients should stay relaxed and not eat cold food. 4. Contraception and epilepsy: Women with epilepsy of childbearing age should choose oral contraceptives containing low-dose estrogen/high-dose progestin, or oral non-hormonal contraceptives, preferably using condoms, uterine caps and intrauterine devices for contraception to avoid contraceptive drugs that aggravate seizures. 5. Pregnancy and epilepsy: The best time to conceive is when the epilepsy has been controlled, no seizures or very few seizures for 2 to 5 years, and then consider stopping the medication before conceiving. If you still need to take medication, you can choose a single drug at low dose, and try to avoid the use of drugs with high teratogenicity such as dalantin and valproate. Avoid the combined application of multiple drugs as much as possible. It is better to divide the dose into 3-4 times a day or use controlled-release tablets to avoid high blood concentration. During the first 3 months of conception, take folic acid daily to reduce the occurrence of fetal malformations, and take oral vitamin K in the last month to prevent intracranial hemorrhage in newborns. 6. Menopause and epilepsy: Whether seizures increase during menopause varies from report to report, but the consensus is that hormone replacement therapy is not recommended for menopausal patients with epilepsy to avoid aggravating seizures. The above describes some precautions for women with epilepsy from the aspects of medication and various important periods for women, hoping to be helpful for women with epilepsy.