Reflux esophagitis after taking rabeprazole and mosapride for half a month does not get better, may be due to increased abdominal pressure, delayed gastric emptying, drug insensitivity, food factors and other reasons. 1. Increased abdominal pressure: patients with excessive obesity, ascites or vomiting and other factors, resulting in damage to the lower esophageal sphincter, often stimulated by these factors, so recurrent episodes, taking medication does not improve, the need to adjust the diet, weight control. 2. Delayed gastric emptying: while taking medication, acid reflux can also occur if you often eat too much or have intestinal obstruction, constipation and other causes of increased pressure in the stomach. 3. Drug insensitivity: may be to rabeprazole and mosapride these two drugs are not sensitive, resulting in half a month after taking the drug does not get better, can follow the doctor’s instructions to replace the other drugs, such as pantoprazole, domperidone and other treatments. 4. Food factors: eating high sugar food, greasy, spicy food can also lead to recurrent episodes of the disease, and no improvement after taking medication. It is recommended to consult a doctor in time to clarify the cause of reflux, targeted treatment, and medication should be used in accordance with the doctor’s instructions.