High thyroid stimulating hormone can be the result of diseases such as primary hypothyroidism, heterogenic TSH secretion syndrome, or after the application of drugs such as dopamine antagonists. Thyroid stimulating hormone is secreted by the pituitary gland and promotes the synthesis and release of thyroid hormones by the thyroid gland, and is also regulated by changes in thyroid hormone levels. Elevated thyrotropin is most commonly seen in primary hypothyroidism or subclinical hypothyroidism, which results in a feedback increase in thyrotropin due to a decrease in thyroid hormone. In addition, a mass in the pituitary gland or elsewhere can lead to elevated heterologous thyrotropin secretion; in addition, high thyrotropin can be seen in conditions such as simple goiter and hyperadenopituitarism. Thyroid hormone may also be elevated in some cases of iodine-containing drugs and dopamine antagonists. Thyroid stimulating hormone is high and requires active medical consultation to identify the cause of the disease and to provide targeted treatment.