Isotretinoin softgels should not be taken with vitamin A. Taking isotretinoin and vitamin A together may increase the toxicity of isotretinoin and can result in symptoms similar to those seen when vitamin A is overdosed, so these two medications should not be taken together. In addition, isotretinoin is contraindicated in women who are pregnant or about to become pregnant. Women of childbearing potential or their spouses should use effective contraception for 3 months prior to initiating treatment with isotretinoin, during treatment, and for 3 months after discontinuing the drug. It is contraindicated in lactating women, hepatic or renal insufficiency, and vitamin A overdose. Patients are advised not to take Isotretinoin and Vitamin A on their own, but to visit a hospital and use the medication under medical supervision.