Renal tubulointerstitial injury may lead to elevated creatinine. Creatinine is the metabolic end product of creatine in muscle tissue, which is mainly excreted from the body by glomerular filtration. If renal tubular damage leads to abnormal renal function, which in turn has an impact on the glomerular filtration function, creatinine can not be normally excreted from the body, which may lead to elevated levels of creatinine in the body. The clinical manifestations of renal tubulointerstitial injury are variable and non-specific. Some patients may have oliguria or anuria with varying degrees of azotemia, and some patients may have symptoms of severe uremia and develop acute renal failure, resulting in elevated creatinine. If the patient has renal tubulointerstitial injury, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.