Acute lymphoblastic leukemia can be treated after relapse, and the treatment methods include general treatment, chemotherapy, hematopoietic stem cell transplantation, etc., which can significantly improve the prognosis of patients. 1. General treatment: after relapse, patients should be actively prevented and treated against infections (levofloxacin); if the anemia is severe, correct the anemia in time, and support with component blood transfusion if necessary; supplement nutrition, give high-protein and high-calorie diet, and improve the immunity of the organism. 2. Chemotherapy: once the disease relapses, re-induction chemotherapy program should be carried out immediately to kill the leukemia cells in the body as far as possible, and it is recommended that the principle of high-dose combined intensive treatment can further improve the complete remission rate of acute lymphoblastic leukemia and prolong the survival period. Such as vincristine, cytarabine, cyclophosphamide, methotrexate and other drugs. 3. Hematopoietic stem cell transplantation: Hematopoietic stem cell transplantation can make about 50% of the patients survive for a long time if conditions permit, which brings hope for the eradication of the disease. If acute lymphoblastic leukemia relapses, it is recommended to consult a doctor for timely and standardized treatment.