Pemerix is a combined estrogen, which is mainly used for the treatment of the corresponding clinical symptoms due to ovarian decline, such as osteoporosis or the development of vaginal atrophy, given with Pemerix. For clinical use of Pemerix, in case of vulvar atrophy, it is advisable to give topical medication with Pemerix ointment. Before using the drug, it is important to have a mammogram, cervical cancer screening and ultrasound to know if the thickness of the endometrium is abnormal. The main purpose is to exclude breast lesions, cervical lesions and endometrial lesions before treatment with Pemerix can be given. In addition, it should not be used if there is a tendency of blood clots, and it should not be used with special caution if there is a history of hypertension.