It is common to have swelling and pain in the hands after tired work. This condition is caused by heavy physical labor, which leads to muscle and ligament damage in the hands and can cause swelling and pain in the hands. Long-term chronic strain, resulting in aseptic inflammation of the joints of the hand, can also appear the symptoms of hand swelling and pain. In this case, we should pay attention to rest and avoid strenuous hand activities. We should pay attention to proper elevation of the hand and avoid prolonged drooping of the hand to avoid aggravating the swelling and pain in the hand. Symptomatic treatment with anti-inflammatory and pain-relieving drugs, such as oral diclofenac sodium, can be used to relieve the symptoms of hand swelling and pain. It can also be treated with oral Chinese medicine that activates blood circulation and relieves blood stasis, such as Wan Tong Tendon Tablet and other drugs, which can promote blood circulation and relieve pain. In addition, the painful area can be treated with appropriate hot compresses or with acupuncture or physical therapy to relieve the pain.