The precursor of waking up of comatose patients with craniocerebral injury will generally be manifested as eye rotation, stabilization of vital signs, response to external stimuli, etc. The appearance of the above situations suggests that the patient may be on the verge of waking up. 1. Eye rotation: although patients may not be able to open their eyes in the early stage, there may be eyelash reflex, the patient’s eyeballs can be clearly seen to the left and right, or the patient takes the initiative to open his eyes, which suggests that the degree of coma is changing from deep to shallow. 2. Vital signs tend to stabilize: the most basic vital signs without treatment, such as blood pressure, heart rate, oxygen saturation, etc., these signs tend to stabilize. Blood routine and biochemical tests of electrolytes and liver and kidney functions also tend to stabilize. 3. External stimulation: from the initial lack of response to painful stimuli, to the appearance of pain, may also appear limb or finger, toe movement. Or can respond to some simple commands, these all suggest that the patient may wake up in the near future. When the patient is unconscious due to craniocerebral injury, he should go to the hospital in time for consultation and active treatment, so as to avoid delaying the condition.