Treatment of pulmonary hypertension in infants includes general supportive care, mechanical ventilation, nitric oxide inhalation therapy, medications, and extracorporeal membrane lung. General supportive therapy. Appropriate nutritional support, appropriate environmental temperature, and sedation for pain relief if necessary. Mechanical ventilation. It can improve the ventilation and blood flow ratio imbalance and reduce the pulmonary artery pressure. Nitric oxide inhalation therapy. Can selectively dilate the pulmonary vasculature of the lungs with good ventilation to reduce pulmonary arterial hypertension, the advantage of fast onset of action, but expensive, and there may be a rebound phenomenon after discontinuation of the drug. Drug treatment: specific medication should be under the guidance of a doctor, not blindly self-medication, in order to avoid adverse effects. 1. Sildenafil. Phosphodiesterase inhibitor, can diastole pulmonary vascular smooth muscle and reduce pulmonary vascular resistance to reduce pulmonary hypertension in children. 2. Bosentan. Endothelin antagonist, preventing or even reversing pulmonary vascular remodeling and right ventricular hypertrophy, reducing right ventricular afterload, and reducing pulmonary hypertension in children. 3. Lung surface active substances. Mainly used for high-frequency oscillatory ventilation and nitric oxide inhalation treatment effect is not good, there is to reduce the tension of alveolar fluid-air plane, to prevent the role of end-expiratory lung collapse, but the price is expensive. Extracorporeal membrane lung. It can effectively improve alveolar gas exchange to improve the survival rate of children.