There is no such thing as a 2-valent E. coli vaccine. 2-valent E. coli vaccine usually refers to the domestic bivalent human papillomavirus vaccine, which can be used to prevent 2 subtypes of human papillomavirus from infecting the organism. At present, bivalent HPV vaccines used for population self-funded vaccination in China include bivalent HPV adsorbed vaccine and bivalent HPV vaccine (E. coli). Both of these vaccines can prevent the two high-risk subtypes of HPV 16 and 18 from infecting the body. The adsorbed vaccine is an imported vaccine and the E. coli vaccine is a domestic vaccine. Bivalent human papillomavirus vaccine (E. coli) is made by introducing human papillomavirus into E. coli as a carrier, with low cost and high yield. Vaccination with this vaccine produces vaccination effects similar to those of imported bivalent HPV vaccines.