The roughness of the gallbladder wall often suggests an inflammatory reaction in the gallbladder, which may be associated with gallbladder stones, cholecystitis and other diseases, and antibiotics, antispasmodics and painkillers should be taken according to the specific situation. 1. Gallbladder stones: gallbladder stones repeatedly rub the gallbladder wall, may cause gallbladder wall roughness. For treatment, for cholesterol stones, commonly used drugs include ursodeoxycholic acid. If the stones are large in size or the body shows corresponding discomfort symptoms, surgical treatment (e.g. laparoscopic cholecystectomy) is considered as the main treatment at this time. 2. Acute and chronic cholecystitis. Inflammatory reaction of the gallbladder can also cause roughness of the gallbladder wall. At this time, the treatment is based on antispasmodic analgesic and anti-inflammatory. Antispasmodic and analgesic drugs include scopolamine, pivacurium bromide and other drugs; anti-inflammatory and anti-infective drugs such as cefuroxime and other antibiotic drugs. If the symptoms are recurrent or unrelieved, cholecystectomy is recommended. The use of the above medications should be in accordance with medical advice. It is recommended that people with rough gallbladder wall should consult a doctor in time, and under professional guidance, further improve the relevant examinations to clarify the cause of the disease, and then proceed to the next stage of treatment.