Antidepressants, a class of drugs for the treatment of various depressive states, contain a large variety and vary somewhat in the types applied for different conditions. They should be applied starting with small doses and the next step of treatment should be decided gradually according to clinical results. When the depressive symptoms have resolved, the treatment should also be continued for 4-6 months with consolidation and maintenance. When discontinuing the medication, it should also be slowly and gradually reduced and stopped. Commonly used antidepressants mainly include: 1, fluoxetine: for a variety of depression, obsessive-compulsive disorder and bulimia patients, adverse reactions are mild, the efficacy is relatively long; 2, paroxetine: for depression with anxiety and panic disorder patients are more suitable, this drug withdrawal needs to be cautious, stopping too quickly can occur adverse reactions; 3, venlafaxine: this drug is fast-acting, suitable for a variety of conditions of depression patients. Adverse reactions are often nausea, sexual dysfunction and insomnia; 4, duloxetine: in addition to severe depression, but also to improve chronic pain and peripheral neuralgia, chronic alcoholism and liver impairment; 5, mianserin: can treat various types of depression, and for major depression has a certain effect, there is a strong sedative and anxiolytic effect, but easy to cause weight gain, excessive sedation and other adverse reactions; 6, bupropion: for two-way depression, excessive sleep and some dementia patients, can also be used for withdrawal reactions and cravings caused by smoking cessation, drug addiction, etc.; 7, Reboxetine: more adverse reactions, such as constipation, excessive sweating, insomnia, restlessness, urinary difficulties, etc., other drug therapy is ineffective before using, individual differences in elderly patients, not easy to master the dose; 8, Trazodone: for patients with It is suitable for depressed patients with anxiety, agitation, sleep and sexual dysfunction, and may produce flu-like symptoms at the beginning of the medication; 9. Agomelatine: It is suitable for adult depression or severe depression patients, with fast onset of action and can improve sleep quality, and is prohibited for those with liver function impairment; 10. Plant Guan Ye Lian Qiao extract: It has the effect of relieving liver fire and depression, and is also used clinically as a proprietary Chinese medicine.