Oxaliplatin is a relatively commonly used platinum-based chemotherapy drug, which belongs to the second generation platinum class and is mainly used for chemotherapy of gastrointestinal malignancies, such as oxaliplatin plus fluorouracil and calcium folinic acid, which belongs to the standard regimen of adjuvant chemotherapy after colorectal cancer surgery. In addition, oxaliplatin can be combined with oral tegeo, which can be applied for some advanced gastric cancer and esophageal cancer. Before applying oxaliplatin, some anti-emetic and reaction-reducing drugs are needed. Generally, the effect of this drug on liver and kidney function is less than the first generation platinum cisplatin, but it may cause some peripheral vascular and nerve reactions, which may lead to numbness of hands and feet. Therefore, before and during the application, it is necessary to pay attention to keep warm and avoid getting cold. If it causes severe peripheral nerve reactions in hands and feet, it is necessary to consider treatment with some nerve-nourishing drugs.