Systemic inflammatory response syndrome SIRS,: is a systemic inflammatory response caused by the uncontrolled self-sustained amplification and self-destruction of the organism due to the action of infectious or non-infectious agents on the organism. It is a clinical process in which the organism experiences an excessive stress response for repair and survival. When the body is hit by exogenous damage or infectious toxic substances, the initial inflammatory response can be triggered, while the body produces endogenous immune inflammatory factors to form a “waterfall effect”. The most likely cause of SIRS is in critically ill patients due to reduced compensatory anti-inflammatory response and metabolic dysfunction, which can lead to multiple organ dysfunction syndrome MODS in severe cases. The following is a brief introduction: systemic inflammatory response syndrome, SIRS, is a new concept based on the understanding of the mechanism of multiple organ insufficiency syndrome, MODS. When the body receives a serious blow, it immediately generates a complex defense confrontation, causing a stress response of the immune system, including the release of a large number of inflammatory mediators, and this defense response, which involves multiple systems of the body, is called SIRS. it is a kind of uncontrolled systemic inflammatory response. The diagnosis is made with two or more of the following clinical manifestations: 1) temperature >38 C or <36 C; 2) heart rate >90 beats/min; 3) respiratory rate >20 breaths/min or hyperventilation with PaCO 2 <32 mmHg; 4) WBC >12×109 or <4×109 or juvenile granulocytes >10%.