Fluconazole can generally be taken with acid suppressants such as omeprazole, gastrointestinal mucosal protectants and other stomach medications, but there is a clear contraindication to taking it with cisapride. Fluconazole is a broad-spectrum antifungal agent for the treatment of fungal infections, and its main use is in the treatment of Candida, Cryptococcus infections, and Coccidioidomycosis. Fluconazole is contraindicated with cisapride, which may cause the same side effect, because of its clear potential to cause prolongation of the QT interval as a side effect. In addition its concomitant use with azithromycin, cyclophosphamide, and NSAIDs such as naproxen and diclofenac may lead to the risk of elevated plasma concentrations of CYP2C9 and others. Fluconazole has some hepatotoxicity and can produce transient serum aminotransferase elevations, requiring caution especially in patients with underlying medical conditions. Renal function abnormalities may occur in certain patients, such as those with severe underlying disease. The medication should be used under the supervision of a physician and should not be used without authorization.