Cold headache and diarrhea can be caused by gastrointestinal cold or cold combined with enteritis. Gastrointestinal cold is caused by coxsackie virus, the most important symptoms are nausea, vomiting, diarrhea, fever, there will be different degrees of headache, nasal congestion, loss of appetite and other symptoms. Treatment is mainly symptomatic, bed rest, eating easily digestible and nutritious food, and drinking plenty of water. Cold combined with enteritis will also appear headache, diarrhea symptoms, mainly for cold caused by immunity decline, gastrointestinal tract is caused by bacterial infection. Treatment is mainly anti-bacterial drugs such as cephalosporin and ofloxacin. If the symptoms of cold, headache and diarrhea are serious, it is recommended to go to the hospital in time to find out the cause of the disease and then targeted treatment. All of the above drugs should be applied under the guidance of a doctor, avoid self-medication.