Neonatal cytomegalovirus infection can be cured in the acute phase. Since most neonatal cytomegalovirus is not diagnosed until the child has symptoms, neonatal cytomegalovirus infection is often associated with complications such as prematurity, low birth weight, jaundice, hepatosplenomegaly, and even mental retardation and thrombocytopenia. Among these symptoms, jaundice and hepatosplenomegaly are the most prominent clinical signs. After a newborn infection, it is important to promptly check the child for intrauterine infection. If cytomegalovirus infection is diagnosed, the child should be promptly given ganciclovir, which has an anti-cytomegalovirus effect, for a course of about six weeks. So most cytomegalovirus infections in newborns are well controlled and the prognosis is better if based on the absence of complications, liver and kidney impairment, and mental retardation.