Cranial bone is a hard and indispensable bone in human body, which plays a pivotal role in the normal operation and health of human life activities. When external factors or the cranial bone itself becomes diseased, it will cause cranial bone defect, which will break the normal trajectory of human life and reduce the quality of life. The main purpose of the surgery is to replace the defective cranial bone with a material similar to the human autologous cranial bone, to repair the bone window of the defective part, to achieve the integrity of the cranium again, to restore the cranial cavity confinement, to maintain the physiological intracranial pressure stability, to reduce the occurrence of cranial defect syndrome; through the defect repair, to achieve the symmetry of the head shape Through the defect repair, the head shape is symmetrical, the appearance is natural and beautiful, and the patient’s inner confidence is improved. In the neurosurgical guidelines, generally 2-3 months after the debridement surgery, the diameter of the defect is greater than 3 cm, which is in line with the indications for surgery, and the patient needs to be repaired in time. The peek material, also known as polyether ether ketone material, has great advantages in repairing the skull. peek material is a light and strong material, and its elastic modulus is very close to that of autologous bone, so patients will not feel any foreign body after using it, and its high hardness will not make patients worry about collapse after being subjected to external force; peek material is permeable to radiation and will not affect postoperative examination. This wear-resistant and corrosion-resistant inert material is non-conductive and non-heat-conductive, and will not be affected by weather changes after use; the most noteworthy is its cosmetic effect, using advanced 3D printing technology to replicate the patient’s defective skull, which will be closely connected with the surrounding bone window, and the head is more smooth and flat.