High immunoglobulin IgE may be caused by the body’s infection with parasites or the occurrence of allergic diseases. 1. Infection with parasites. When the human body is infected with certain parasitic diseases, such as roundworm and schistosomiasis, it is easy to cause the immunoglobulin IgE in the serum to be elevated. At the same time, there will also be other clinical symptoms caused by parasites, attention to do the parasite egg test to confirm the diagnosis. 2. Allergic diseases. Immunoglobulin IgE is mainly involved in type I allergic reactions, if immunoglobulin IgE is elevated in human serum, it may also be caused by type I allergic diseases. For example, allergic rhinitis, allergic asthma and allergic dermatitis, as well as chronic urticaria. It is recommended to consult a doctor promptly to clarify the cause of the disease and treat it aggressively.