According to the pain score of 1-3, it is categorized as mild pain, and NSAIDS can be applied to relieve pain, but it has both advantages and disadvantages Any one of the NSAIDs has good tolerance and efficacy in patients with mild cancer pain. Among the commonly used “non-tendency COX inhibitors”, diclofenac sodium has strong anti-inflammatory and analgesic effects and is well tolerated; indomethacin and piroxicam have strong anti-inflammatory and analgesic effects but are poorly tolerated in the gastrointestinal tract. Naproxen and ibuprofen are milder and better tolerated by the gastrointestinal tract. Therefore, it is recommended that young adult patients without gastrointestinal disorders should choose the affordable traditional NSAIDs.He Jie, Department of Oncology, Zhangqiu People’s Hospital Nabumetone and meloxicam have strong anti-inflammatory and analgesic effects, and have fewer gastrointestinal side effects due to their weak inhibitory effect on COX-1. Nabumetone is non-acidic and has no direct irritant effect on the gastrointestinal tract, which makes it safer in the gastrointestinal tract compared to conventional NSAIDs, and has a long half-life of once-daily dosing. Nimesulide is a special NSAIDs, it is not too strong analgesic effect on arthritis, but has a good anti-inflammatory and antipyretic effect.In the late 90’s, nimesulide treatment of arthritis, with a long course of medication, and its liver toxicity, should be noted. Since the analgesic effect of nimesulide on arthritis is not strong, and its hepatotoxicity is more obvious than other NSAIDs, we do not advocate its use in the treatment of arthritis. However, it has specific efficacy in some non-infectious, non-tumorigenic fevers and/or inflammatory conditions, such as adult Still’s disease and reactive lymphadenitis. Therefore, it has better efficacy when applied when considered as cancer pain with tumor fever.