Sprained ankle swelling and pain can be reduced through general treatment, physical therapy, drugs, surgery and other ways to reduce swelling and pain. 1. General treatment: After the injury, we should pay attention to rest, reduce the stimulation of the affected area. You can also elevate the affected limb and apply an elastic bandage to help relieve the swelling and pain. 2. Physical therapy: in the sprain of 72h acute period can be cold compresses, cold compresses can reduce inflammation, relieve swelling and pain. Hot compresses in the recovery period after 72h can promote blood circulation and promote the recovery of swelling and pain. 3. Medication: non-steroidal anti-inflammatory drugs such as ibuprofen can be used to relieve pain. 4. Surgery: If the sprain is serious, it may cause fracture and other injuries. If the fracture is not obviously displaced, it can be fixed with plaster or support. If the fracture is not significantly displaced, it can be fixed with a cast or brace. If it is seriously displaced, it needs to be fixed with surgical incision and reset. After the ankle sprain, you need to go to the hospital in time for further examination and treatment. The above drugs need to be applied under the guidance of a physician.