Symptoms of recurrent diffuse large b-cell lymphoma include enlargement of localized lymph nodes and symptoms in the affected area, such as headache, nausea, vomiting, blurred vision, visual field defects, etc. in the central nervous system. When diffuse large b-cell lymphoma recurs, in addition to localized lymph node enlargement, central nervous system involvement, hilar and mediastinal involvement, pharyngeal lymphatic ring involvement, gastrointestinal tract involvement, testicular involvement, skin involvement, and bone damage may also occur. 1. Central nervous system involvement may include headache, nausea, vomiting, blurred vision, and visual field defects. 2. Lung portal and mediastinal involvement may be characterized by enlarged supraclavicular cervical lymph. The presence of pleural effusion may lead to symptoms such as coughing, chest tightness, and shortness of breath, and the presence of pericardial effusion may lead to symptoms such as shortness of breath, chest pain, dyspnea, and tachycardia. 3. Involvement of the pharyngeal lymphatic ring manifests as dysphagia, nasal congestion, rhinorrhea and enlarged submandibular lymph nodes. 4. Gastrointestinal involvement mainly manifests as abdominal pain, diarrhea and abdominal mass. 5. Testicular involvement may be characterized by testicular swelling and pain, abdominal pain and abdominal effusion. 6. Skin involvement may be characterized by subcutaneous nodules, lumps and ulcers. 7. Bone involvement may manifest as bone pain. It is recommended to go to the hospital in time when the above symptoms appear, so as to have regular treatment as soon as possible.