The most common side effects of azithromycin, such as symptoms of digestive system, vascular irritation and peripheral allergic reactions. I. The appearance of nausea, vomiting, acid reflux and heartburn in the digestive system are the biggest side effects of azithromycin application, which can be relieved by applying drugs that inhibit excessive secretion of gastric acid, proton pump inhibitors and gastric mucosal protectors such as omeprazole, rabeprazole, thioglycollate and other drugs. Second, the side effects of vascular irritation such as injection of local vascular pain, you can slow down the titration rate or adjust the titration rate to about 7-15 drops/min to observe the situation, you can also perform local hot compress treatment. In case of serious allergic side effects, desensitizing drugs should be applied immediately. Antihistamines can be applied in mild cases, adrenal glucocorticoids should be applied in moderate allergy, and epinephrine must be applied in the most serious side effects.