There are many possible reasons for the occurrence of limb weakness and panic. For electrolyte disorders, they can cause bradycardia, tachycardia and limb weakness, while for electrolyte disorders, they can occur in patients with renal insufficiency and in patients with heart failure undergoing diuretic therapy. In addition, weakness and panic in the extremities are commonly caused by organic heart disease, such as common acquired heart disease, coronary heart disease, hypertensive heart disease, valvular disease, myocarditis, cardiomyopathy, infectious myocardial or endocardial lesions, etc., which can lead to weakness and panic in the extremities. In addition, endocrine diseases, such as hyperthyroidism, may also cause panic and weakness of the limbs. Patients with secondary hypertension, such as primary hyperaldosteronism, may also experience panic and weakness of the limbs due to low potassium.