Melanin deposits on both sides of the cheeks, common diseases include follicular erythema nigricans of the face and neck, which can be treated by drugs and physical therapy. 1. Medication: It is recommended that patients use retinoic acid drugs such as retinoic acid ointment and arbutin under the guidance of doctors to promote skin metabolism and improve the symptoms of melanin deposition. 2. Physical therapy: For patients with ineffective drug treatment or large melanin deposits, physical therapy such as laser can be used to remove melanin deposits. In addition, such as sun exposure, cosmetics, drugs, etc. may aggravate the precipitation of melanin on the face. It is recommended that patients take measures such as paying attention to sun protection, reducing the use of cosmetics, stopping the use of related medications, etc., and consulting a doctor in a timely manner to avoid further aggravation of the condition by following the doctor’s instructions and using medication.