Peptic ulcer generally refers to peptic ulcer, clinical manifestations mainly include epigastric pain, belching and heartburn, nausea and vomiting. Peptic ulcer refers to a variety of pathogenic factors under the action of the mucous membrane inflammation and necrotic lesions occurring deep or penetrate the mucous membrane muscle layer resulting in ulcers. It often occurs in the mucosa of the digestive tract in contact with gastric acid, and is most common in the stomach and duodenum. 1. Upper abdominal pain: it is the most common symptom of peptic ulcer, mostly manifested as chronic upper abdominal pain or hidden pain. In some patients, the pain is aggravated after eating, which mostly belongs to gastric ulcer; the pain during hunger is considered to be duodenal ulcer. 2. Belching and heartburn: mostly seen in young patients with duodenal bulbous ulcers, can be accompanied by pyloric spasm. Heartburn (also known as heartburn) is located in the fossa of the heart or behind the raphe, seen in 60% ~ 80% of patients with ulcer disease, patients with high acid secretion. 3. Nausea and vomiting: Vomiting in ulcer disease is gastric vomiting, which is reflex vomiting. Vomiting is often preceded by nausea and associated with eating, but nausea and vomiting are not symptoms of simple gastric and duodenal ulcers. Vomiting in patients with peptic ulcers is likely to be associated with gastric retention or irritation from ulcers near the pylorus. Once these discomforts occur, it is important to go to the hospital and follow the doctor’s instructions for acid-suppressing treatment, such as the use of omeprazole and famotidine, after diagnosis.