Cotrimoxazole capsule is a cold relief medicine and Amoxicillin capsule is an antibiotic antimicrobial. For common cold with symptoms of runny nose, sneezing and dry and itchy throat, you can take Cotrimoxazole capsule twice a day, one capsule at a time. Amoxicillin is not needed for common cold, when there is inflammation of tonsils, acute bronchitis or pneumonia, you can take Amoxicillin. If you are not sure, it is recommended to go to the hospital for examination and decide which medicine to take according to the specific situation.