The difference between mupirocin ointment and fusidic acid cream includes ingredients, indications, and adverse reactions. 1. Ingredients: mupirocin ointment is mainly composed of mupirocin, and fusidic acid cream is mainly composed of fusidic acid. 2. Indications: Mupirocin ointment is commonly used in the treatment of skin infections caused by gram-positive cocci, such as impetigo, boils, folliculitis, etc.. Fusidic acid cream is often used to treat skin infections caused by staphylococcus, streptococcus, propionibacterium acnes and other fusidic acid-sensitive bacteria, such as onychomycosis, folliculitis, acne vulgaris and so on. 3. Adverse reactions: some patients may experience adverse reactions such as burning sensation, itching, stinging sensation as well as rash and swelling after topical application of mupirocin ointment. Adverse reactions of fusidic acid cream include localized eczema, contact dermatitis, erythema as well as papules and purpura. It is important to note that mupirocin ointment and fusidic acid ointment are contraindicated for those who are allergic to them. There are many differences between mupirocin ointment and fusidic acid cream, it is recommended to go to a regular hospital to consult a doctor to understand the relevant matters, and use the medication under the guidance of the doctor, do not use the medication without authorization.